Quantitative Comparative Proteomics Reveal Biomarkers for Dengue Disease Severity

Proteomics-Based Disease Biomarkers

Sequencing of the human genome has greatly impacted the proteomics-based analysis of disease by providing a framework for understanding the proteome of diseased cells, tissues, and biological fluids. Consequently, there is a growing interest in applying proteomics technologies to define protein pathways involved in various diseases, to identify new biomarkers that correlate with diseases, ideal...

Proteomics used to identify potential biomarkers for dengue hemorrhagic fever

Neuropathic pain is a condition that causes major chronic pain in millions of people worldwide. The reasons that cause this pain to persist remain unclear, and treatment has been inhibited by a lack of understanding of the chemical basis of this pain. Researchers have recently implicated dimethylsphingosine (DMS) as a molecule that is associated with inducing neuropathic pain. The group, led by...

Proteomics Discovery of Disease Biomarkers

Recent technological developments in proteomics have shown promising initiatives in identifying novel biomarkers of various diseases. Such technologies are capable of investigating multiple samples and generating large amount of data end-points. Examples of two promising proteomics technologies are mass spectrometry, including an instrument based on surface enhanced laser desorption/ionization,...

Quantitative Dengue Test: Is it Practical for Clinical Practice?

Markers of dengue disease severity.

Infection with one of the four serotypes of dengue virus (DENV) causes a wide spectrum of clinical disease ranging from asymptomatic infection, undifferentiated fever, dengue fever (DF) to dengue hemorrhagic fever (DHF). DHF occurs in a minority of patients and is characterized by bleeding and plasma leakage which may lead to shock. There are currently no reliable clinical or laboratory indicat...